![]() The word 'curare' is derived from wurari, from the Carib language of the Macusi of Guyana. ![]() Further details may exist on the talk page. Please expand the section to include this information. This section is missing information about use of curare by Central American people. Historically, curare has been used as an effective treatment for tetanus or strychnine poisoning and as a paralyzing agent for surgical procedures. Curare is prepared by boiling the bark of one of the dozens of plant alkaloid sources, leaving a dark, heavy paste that can be applied to arrow or dart heads. This causes weakness of the skeletal muscles and, when administered in a sufficient dose, eventual death by asphyxiation due to paralysis of the diaphragm. These poisons function by competitively and reversibly inhibiting the nicotinic acetylcholine receptor (nAChR), which is a subtype of acetylcholine receptor found at the neuromuscular junction. Used as a paralyzing agent for hunting and for therapeutic purposes, Curare only becomes active by a direct wound contamination by a poison dart or arrow or via injection. Strychnos toxifera, the Strychnos species which is the principal source of 'Calabash Curare' and its main active constituent - the alkaloid toxiferineĬurare ( /kʊˈrɑːri/ or /kjʊˈrɑːri/ koo-rah-ree or kyoo-rah-ree) is a common name for various plant extract alkaloid arrow poisons originating from indigenous peoples in Central and South America.
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